![]() ![]() Good Foods and Ingredients to Include in Your GERD DietĪccording to, there are a number of foods we can include in our diet to fight GERD symptoms. Treat this recipe like a master cookie dough and. Citrus fruits like grapefruit and oranges This is my go-to recipe when I want to make a classic chocolate chip cookie, but feel free to swap the chocolate for any other fillings you fancy.Since certain kinds of food and ingredients can increase the risk of experiencing GERD symptoms, it’s best to avoid them. So, how do we avoid GERD symptoms? Avoid GERD Triggers in Your Diet Feel like there’s a lump in your throat.The types of food we eat and the ingredients we use in recipes can cause heartburn and acid reflux. Because the muscles are weak, they allow the flow back (reflux) of stomach acid and food. Gastroesophageal Reflux Disease (GERD) is a disorder in which the ring of muscles that separates the esophagus and the stomach becomes weak causing acid reflux or heartburn. Julie Wei has outlined a comprehensive list of causes and symptoms that may be impacting your child.A great way to avoid the symptoms of heartburn and acid reflux is to develop a GERD diet. Until the medical field formally recognizes this condition, MCD will continue to be misdiagnosed as a wide variety of illnesses.ĭr. Conventional treatments don’t work because the real cause has not been identified. We rounded up the best cookie recipes of all time, from snickerdoodles to chocolate chip cookies and all types of cookies in between. The child is given another prescription.But, what if the physician has not identified the exact cause? If the physician has identified the exact cause and prescribed the proper treatment, the child should get better. The child may even be referred to specialists (like a pulmonologist, allergist or ENT). ![]() The physician makes a diagnosis based on their best “guess.”īased on the doctor’s assumptions, medications are then prescribed, such as inhalers, nasal spray and antihistamines or antibiotics.There is little or no discussion regarding what the child is eating and when, or other diet and lifestyle habits (like a lack of exercise).The child is examined and the pediatrician believes that the child is truly sick based on the symptoms.The parents/caregivers share that these symptoms are not going away.A child with symptoms is seen by his or her pediatrician.Long term exposure to acid reflux can cause a variety of medical problems suchĪs asthma, bronchospasm, chronic cough, hoarseness, dental problems, andĬONVENTIONAL TREATMENT Our current medical system works like this:.Arrange them in an even layer across the pan, then sprinkle salt and pepper on top. On the prepared baking sheet, toss the broccoli with the oil until all of the florets are lightly coated. We use strictly necessary cookies, performance cookies and functional cookies so our website can be operated safely, its contents and services can be used and. Line a large, rimmed baking sheet for easy clean-up, if desired. ![]() These symptoms are most commonlyīlamed on allergies, infections, or a cold, by adults and doctors. Preheat the oven to 425 degrees Fahrenheit. Nose, cough, sore throat, and even croup. My Carrot Cake Oat Cookies are sweetened naturally with dates, coconut and almond meal thus NO ADDED SUGARS And the recipe is definitely plant-based (oats, dates, carrots, raisins, almonds and, of course, the cashew-based Forager Cashewmilk Yogurt). Instead, they typically have congestion and runny Its best to take these with food or soon after eating, as this is when.
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![]() ![]() It’s just made my love for it grow even more. I think in the past year and a half it has been amazing to really get out there perform gigs, play festivals and meet people in person. I’d done some Zoom interviews and that kind of thing, but I hadn’t really met anyone. I had released a whole EP and I never really left my house. I started releasing music properly at the end of 2020 but, it was still during lockdown so the first whole year of releasing music. Since 2020, you’ve had quite a meteoric rise, how does that feel?Īmazing. Three or four year old little Lea saw herself on the stage and that’s kind of where it started from. I think the more I do it the more passionate I get about it and the more I want to keep doing it and keep getting better. I feel so lucky to be doing something that makes me so happy every single day. ![]() ![]() Then when I got into my teenage years, I realised it was something I wanted to take more seriously. Growing up it was really an outlet for me to do that. Since I was four or five, music was always my way to express myself. Hey Lea, how are you? So what first got you interested in music? We got the chance to chat to Lea all about writing the song, what’s next for her and of course what her favourite Cadbury’s chocolate is. Recently, Lea was given the opportunity to write a song to incorporate all the excitement around the Irish women’s football team headed over to Australia to play in the World Cup for the first time. Kildare singer-songwriter, Lea Heart, started posting to TikTok at the same time as everybody else but instead of being at home, she’s now playing sold out headline shows at the 3Olympia and opening for Lewis Capaldi at the 3Arena. One Irish singer took to the platform to create videos out of boredom and it completely changed her life. It was clear TikTok would change the trajectory for many, as the social media platform gained popularity week in and week out. ![]() Whether you were watching others or contributing to the video content, it didn’t matter. by Word Music Group, Inc.When lockdown hit in 2020, TikTok became the entertainment choice for over 315 million people worldwide. by Essential Music Publishing LLC) Weave Country (Admin. by Essential Music Publishing LLC) So Essential Tunes (Admin. of Word Music Group, Inc.) Open Hands Music (Admin. 2 If I told you my story You would hear Hope that wouldn't let go And if I told you my story You would hear Love that never gave upģ And if I told you my story You would hear Life, but it wasn't mineĤ If I should speak then let it be Of the grace that is greater than all my sin Of when justice was served and where mercy winsĥ Of the kindness of Jesus that draws me in Oh to tell you my story is to tell of HimĦ If I told you my story You would hear victory over the enemy And if I told you my story You would hear freedom that was won for meħ And if I told you my story You would hear Life overcome the graveĨ If I should speak then let it be Of the grace that is greater than all my sin Of when justice was served and where mercy winsĩ Of the kindness of Jesus that draws me in Oh to tell you my story is to tell of Himġ0 This is my story, this is my song Praising my savior all the day long (repeat)ġ1 For the grace that is greater than all my sin Of when justice was served and where mercy wins Of the kindness of Jesus that draws me inġ2 Oh to tell you my story is to tell – Of the grace that is greater than all my sinġ3 Of when justice was served and where mercy wins Of the kindness of Jesus that draws me in Oh to tell you my story is to tell of Himġ4 Oh to tell you my story is to tell of Himġ5 This is my story, this is my song Praising my Savior all the day long (end)ġ6 “My Story” words and music by Jason Ingram, Mike Weaver © 2014 Word Music, LLC (a div. ![]() ![]()
![]() ![]() Download our iOS app now and explore how we can assist you in achieving eCommerce success with Magento. With our comprehensive range of Magento services and expertise, we are committed to helping you optimize your eCommerce business on iOS, driving growth, and delivering exceptional customer experiences. Hire a Developer: Our app also provides access to a dedicated team of Magento developers, offering flexible and tailored solutions for your iOS project. Toolbank Integration: Integrate your Magento store on iOS with leading ERP systems, CRMs, payment gateways, shipping providers, and other third-party tools to streamline operations and enhance efficiency. 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Reduce your misophonia triggers with this app. Magento 1 to Magento 2 Upgrade: Seamlessly upgrade your existing Magento 1 store to the latest version of Magento 2 with our migration services, ensuring a smooth transition while preserving your data, customizations, and extensions.ĭata Migration: Effortlessly transfer your valuable data from your current eCommerce platform to Magento on iOS, ensuring a secure and accurate transfer of products, customers, orders, and other crucial data.Įxtension Development: Our skilled developers can design and develop custom extensions to enhance the functionality and performance of your Magento store on iOS.ī2B eCommerce Solutions: Unlock the potential of B2B eCommerce on iOS with our specialized solutions, including personalized pricing, bulk ordering, quote management, and seamless integration with ERP systems. Magento Consultant: Our experienced Magento consultants are available to provide expert advice and guidance for your online business on iOS. Here's an overview of the services we offer: Instead, it acts as a digital portfolio, offering a comprehensive overview of our expertise and the services we deliver. It does not involve any complex operations or transactions. The primary focus of the app is to present our services in an easily accessible manner, providing informative pages that describe each service in detail. ![]() It offers a simple and user-friendly interface, allowing users to explore and learn about the various services we offer. This app serves as an informative platform, providing details about the services we provide. ![]() In our pursuit of digital excellence, we have developed a dedicated iOS app to provide details of our wide range of services. When the oceanhorn sounds in the badland, there may be special opportunities for aquatic monsters and hidden dino bash.Empower Your eCommerce Success with Us: Unleash its Full Potential! Help your primitive brother in arms survive in the land of octogeddon! Dont starve to death- don't forget that wilderness can be a growtopia!Īs a forager, collect creatures and materials for wildcraft levelling up, and strengthen your army with your new wild craft weapons and artifacts! Gather unique animals and mythical creatures to become your next neopet!īattle wild animals, successfully tame the creature, and level up your animal super squad! Or if you are daring, perhaps you may be able to become a mystical dragon tamer. Summon your guardian alpha wolf and become a leader of a wolf pack, or simply amass a threatening army swarm of pocket ants at your command! Tame battle cats, monsters, and hybrid animals and take part in the league for pocket taming games!Īs a Wild Tamer, you will be able to win over enemy monster beasts to become your minion. Tired of the gacha life? Enter the ancient wild darkness of druid and necromancer animal jam battlegrounds.īecome a grounded master beast tamer, and capture various critters to do your bidding! ![]() ![]() ![]() ![]() Stir until the dry mixture is smooth, and the lumps are gone! How to Make Corn Pudding Here is a simple recipe you can use:Ĭombine the first 5 ingredients in a bowl and mix well. If you can’t find the Jiffy cornbread mix anywhere, just use another cornbread mix. You can also re-warm in the crockpot.If you have some fresh corn kernels you’d like to use – go right ahead! Fresh corn would be super delicious in this recipe. To reheat a larger amount, place in a greased baking dish and bake at 325✯ until heated all the way through. ![]() To reheat, thaw in the fridge if frozen then microwave single servings until warmed through. Leftovers will last in an airtight container in the fridge for 3-4 days or in the freezer for up to 2 months. Try my Mexican street corn spoon bread.Ĭorn pudding is a classic holiday side dish! I love to serve it alongside other delicious seasonal side dishes. Add meat. Add bacon bits for a delicious smoky flavor and crunchy texture.Use a different cheese. Try pepper jack, monterey jack, gouda, etc.I love this slow cooker corn pudding as-is but if you want to switch the flavors up, here are some ideas! Serve immediately, hot, from the crockpot or re-heat in the microwave until warm. Is corn pudding served hot or cold?Ĭorn pudding is best served warm. If you forgot to drain the canned sweet corn, try giving the pudding a stir, then cook for additional time with the lid OFF - this should help some of the liquid evaporate. Otherwise your corn pudding will be too moist! If your corn pudding came out watery, you may have forgotten to drain the canned sweet corn.Īlthough you do want the added moisture from the creamed corn, you want to make sure you drain the sweet corn before adding that to the crockpot. You’ll know it’s done when the mixture is slightly set but still creamy and delicious. How long to cookĬook corn pudding in the crockpot on HIGH for 5 hours. Test the recipe out BEFORE you’re serving this to guests so you’ll know if you need more or less time than what’s listed in the directions. Salt and Pepper – cuts the sweetness and adds a touch of spice.Ĭrockpot temperatures may vary based on brand, age of the product, etc.Granulated Sugar – adds just a touch more sweetness to enhance the corn flavor.Cornbread Mix – our base! I use Jiffy cornbread mix, but other brands will work as well!.Eggs – gives the other ingredients some structure to achieve that pudding-like texture.Buttermilk – melts into the other ingredients to form a delicious creamy texture.Also helps to create that ooey-gooey texture. Sharp Cheddar Cheese – adds a sharp, cheesy flavor to balance out the richness of the other ingredients.Sour Cream and Cream Cheese – provide a tangy flavor and creamy, rich texture.Unsalted Butter – gives the pudding even more moisture and richness.Sweet Corn – adds a pop of texture and sweetness.Cream-Style Corn – makes the pudding ultra creamy and provides a sweet corn flavor.This simple list of ingredients comes together to make a flavorful holiday side dish! A corn casserole has more structure (like a loose cornbread.) Corn pudding, on the other hand, has a smoother, creamier, more custard-like texture…hence the word pudding in the name! Ingredients This is definitely going to be a favorite at the Thanksgiving table! What is corn pudding?Ĭorn pudding is a classic holiday dish! Although pudding does imply “dessert”, and corn pudding is sweet, this pudding is a savory dish made up of creamed corn, cornbread mix, and other ingredients.Ĭorn pudding is similar to corn casserole in ingredients (cornbread mix, corn, sour cream, butter), but the texture is slightly different. Loaded with corn, a little sweet, a little salty, a little tangy, and a whole lot of creamy. This slow cooker corn pudding might just be my new favorite Thanksgiving recipe…like, ever! ![]() ![]() ![]() The functions now are lined up on the bottom of the display for air crisp, roast, grill, bake, broil and dehydrate. old – quite an improvement as you can see. My only grumble would be the scrolling words as you make selections – if the display could have just been a little larger to accommodate more characters. The new control panel is all touch control and the display is nice a clear. With more shiny chrome-like accents, it looks like a premium device and definitely an upgrade. OK, how about the device itself? It is a much more polished looking device compared to the OG. Done with no problem in about 30 seconds!!! Very nice touch with the QR Code!! One thing to remember once you get this out of the box – REGISTER your device and get your warranty set up! This has been made super easy for you now! Simply use your phone and scan the QR code on the back of your device (shown below!) This will take you to the Ninja site where you can register the unit. Here are some internal shots to give to an idea of how the new unit looks inside. They explain the cooking process and the importance of resting/carry-over cooking as well as diagrams on how to place the new smart probe. Instead of the meat temperature sticker, (no longer required!!), there are a couple of different stickers on the new unit. Here is the empty grill, air crisp basket in place and finally the grill plate in place ready to go! Note, to answer the question always asked in the group – leave the sticker on the base of the grill in place! This pops in and out with one sprung clip and it a little easier to remove than the OG filter. The heating element is now covered by a much smaller circular plate. There are noticeable differences shown below too in the design. The new Smart XL grill is much more shallow than the original Ninja Grill device. Tucked inside the grill is the air crisp pan.Īs you can see the packaging is well done and everything is held in place for shipping. This thing comes well wrapped and protected! Here is the difference in the height of the grill fins, not as tall (XL grill plate is the bottom one) ![]() This is one reason I ended up favoring the GrillGrates for my Ninja’s – time and testing will see how the new one works out. One advantage of this is that it should be much easier to clean! The old grill plate for me was always frustrating to clean – even with the Dawn Powerwash and a good soaking. Another interesting note, the spiraling fins on the new grill plate are lower profile. The plate is wider for sure but slightly less tall, comparison pictures below. the old grill plate, not sure if it has changed or the coating on my old one is just seasoned (read used and abused!) now. I’ll say this the Ninja Foodi Smart XL Grill is really well packaged!! In the box is a nice envelope with the recipe book and instructions, complete with cooking charts.įirst up are the new larger grilling plate and the trusty cleaning brush!įirst observations, the coating feels different on the new grill plate vs. So what are we in for, what’s in the box? BOOM! Ninja Foodi Smart XL Grill has landed!Īre you ready for a quick unboxing? I was going to do a video unboxing but with 9 kids running around you’d probably not hear a thing!! ![]() ![]() ![]() ![]() While a fresh coating of snow is possible by early next week, the temperature will rise back to more bearable levels just after Christmas day (highs in the 30s).Ĭopyright 2022 WSAZ. With weekend lows expected to be in the single digits, we will be on frozen pipe alert as the cold wave takes hold. After a dry spring with an overall lack of rain and. Chief Meteorologist Tony Cavalier shares his latest edition of. (WSAZ) - The weather so far this week has been ideal for travelers with dry roads and fair skies within a tankful. (WSAZ) -The atmosphere this Sunday evening is finally taking on the familiar hazy, tropical sky look of summer. Even when the sun comes out the temperature will hover near 15 degrees all day long (and that’s without the wind factored in). As the calendar turns from spring to summer, there is no shortage of wild geological and weather events across the globe to look at. Given rain will precede the arctic front and be followed by wind blown snow showers, an ice-up followed by an accumulation of snow will make for hazardous travel conditions for the first light of Friday.įriday will turn into a harshly cold day with bitter blusters and occasional snow showers sweeping through. And that trend should continue Wednesday as sunshiny skies usher in the winter season with the solstice at 4:47 in the afternoon.Īfter that, the weather will go downhill as first wet then icy roads will confirm the notion that winter is here! The timing of the arrival of the arctic air and wind-blown snow showers is centered around midnight Thursday into Friday morning. (WSAZ) - The weather so far this week has been ideal for travelers with dry roads and fair skies within a tankful of gas of our region. And the final piece of the high water puzzle is the weak wind flow aloft which allows those storm trains to form and meander at a snail’s pace.HUNTINGTON, W.Va. (WSAZ) - Everyone loves a white Christmas. Second a stalled front across the region which focuses the area where showers and downpours can form. Winter Weather Possibilities with Chief Meteorologist Tony Cavalier. First the humid tropical air that is moisture laden. Chief Meteorologist Tony Cavalier provides an update on the polar vortex and the weekend ahead. Check current conditions in Haidian District, Beijing, China with radar, hourly, and more. The nemesis for the heavy rains falls squarely on the shoulders of three separate entities. Wsaz Weather Tony Cavalierthat repuation. 911 dispatchers also reported high water in Martin, Magoffin and Pike counties but not to the extent of Floyd.Īcross the Tug Fork into southern Mingo County, West Virginia, Gilbert Creek overflowed onto rural roads and swamped some low-lying areas near the filling station. ![]() In hard hit Floyd County, Kentucky, a train of rainstorms (one downpour after another moving over the same wet ground) swamped parts of the county (Cow, Ivy and Abbot Creeks). ![]() Turned out the flooding of Tuesday nailed a handful of counties in the coalfields while leaving most areas with a rather benign rain pattern. Cicalese comes to WSAZ from KGWN-TV CBS 5 News in Cheyenne, Wyoming. She will join meteorologists Brandon Butcher, Josh Fitzpatrick, and chief meteorologist Tony Cavalier on WSAZ’s First Warning Weather team. (WSAZ) -After a “localized” severe Appalachian rain day on Tuesday, prospects for more high water are on the table again Wednesday. HUNTINGTON, WEST VIRGINIA - WSAZ Newschannel 3 has announced the hiring of award-winning broadcast meteorologist Kelly Ann Cicalese. ![]() ![]() ![]() To install PowerToys using Scoop, run the following command from the command line / PowerShell: scoop bucket add extras If you have issues when installing/upgrading, create an issue at the maintainers GitHub repository or follow the Chocolatey triage process. To upgrade PowerToys, run: choco upgrade powertoys To install PowerToys using Chocolatey, run the following command from your command line / PowerShell: choco install powertoys These community-driven alternative install methods are not officially supported and the PowerToys team does not update or manage these packages. In case there are problems with uninstalling a version, there are cleanup scripts available: \EXECUTABLE_INSTALLER_NAME.exe -extract_msi and this will extract the MSI to your desktop. You'll want to change the EXECUTABLE_INSTALLER_NAME to what the file name actually is. If you have an issue where the MSI is not accessible, you can download the installer, that corresponds with the installed version, via the PowerToys release page and then run the following command. \dark.exe -x $"\Desktop\PowerToysSetup-0.53.0-圆4.exe"įixes for uninstalling 0.51 and earlier builds issues # dark.exe -x OUTPUT_FOLDER INSTALLER_PATH This PowerShell example assumes the default install location for Wix toolset 3.11.2 and the PowerToys installer downloaded to the desktop. Make sure you have Wix toolset installed. Here are the common commands you may want: Command The installer executable accepts the Microsoft Standard Installer command-line options To install PowerToys using the Windows Package Manager, it is as simple as running the following command from the command line / PowerShell: winget install Microsoft.PowerToys -source winget You must be using the new Microsoft Store which will be available for both Windows 11 and Windows 10. Install from the Microsoft Store's PowerToys page. Once downloaded, open the executable file and follow the installation prompts.Select the PowerToysSetup-0.#.#-圆4.exe or PowerToysSetup-0.#.#-arm64.exe file to download the PowerToys executable installer.Select the Assets drop-down menu to display the files for the release.Visit the Microsoft PowerToys GitHub releases page.To install PowerToys using a Windows executable file: ![]() ![]() It has all the features you need to view, edit, and convert PDF files. Which Adobe Reader Is Best For Mac?Īdobe Acrobat Pro DC is the best Adobe Reader for Mac. Finally, make sure that you are trying to download Reader from the correct download page. Another reason could be that you don't have enough free space on your hard drive. One reason could be that your Safari Security Preferences are not set to allow JavaScript. There culd be several reasons why you can't download Adobe Acrobat DC on your Mac. Why Can't I Download Adobe Acrobat DC On My Mac? If none of these solutions work, contact Adobe customer support for more help. You can also try opening the Adobe Acrobat application directly from the Applications folder, rather than using Launchpad or Spotlight. If you're sill having trouble, try uninstalling and reinstalling Adobe Acrobat. If there is an update available, update your device. You can check for updates by going to System Preferences > Software Update. If that doesn't work, make sure that your Mac is connected to the Internet and that it is running the latest version of macOS. There are several possble reasons why Adobe Acrobat might not be working on your Mac. There are also versions available for Windows, and mobile versions for iPhone and Android that offer pared-down elements of the app. ![]() Yes, Adobe Reader works on Mac computers. (If you don't see the file, choose Downloads from the Chrome menu.) Double-click Install Adobe Acrobat Reader DC to start the installation. When the file appers at the bottom of the browser, click the file. To download Adobe Acrobat Reader DC to your Mac, go to the Adobe Acrobat Reader download page and click Download Acrobat Reader. Once you've signed in, follow the on-screen instructions to complete the download process. If you don't have an Adobe ID, you can create one for free. ![]() You will be prompted to sign in with your Adobe ID and password. Simply select the software you wish to download, then click on the “Download” button. Downloading Adobe software is easy and can be done directly from the Adobe website. Adobe offers a wide range of software for Mac users, including Creative Cloud, Photoshop, Lightroom, and more. ![]() ![]() ![]() It is difficult to predict the prognosis of patients with RCC because of its heterogeneous biological nature. Besides, we also did not detect the publication bias, which indicates the reliability of our study. We also performed sensitivity analyses, and the trend of adjusted results did not alter. ![]() Although heterogeneity existed after subgroup analyses, it decreased in several subgroups. As for patients of different regions, the pooled results are consistent with previous results. In patients with different stages of RCC, there was also a significant association between mGPS and survival. In different cutoff values, the mGPS also could be considered as a predictive factor for survival. We found that higher mGPS results in poorer OS and CSS in patients with clear cell RCC and other RCC. Since there was obvious heterogeneity among studies, we carried out subgroup analyses based on pathological type, the cutoff value of mGPS, stage, and regions. The pooled results suggested that higher mGPS was significantly linked with decreased OS and CSS and increased risk of recurrence and progression. Our studies pooled all eligible studies to evaluate the association between mGPS and survival in patients with RCC. Detailed results of subgroup analyses are summarized in Table 2. Besides, heterogeneity was reduced in several subgroups. The subgroup analyses based on regions show that both Asian and Western patients with higher mGPS had a decline of OS and CSS. For advanced/metastatic or all stages of RCC, there was also a significant association between mGPS and survival. In patients with localized RCC, increased mGPS was correlated to inferior OS (HR=3.93 95%CI, 2.13–7.27) and CSS (HR=3.91 95%CI, 1.94–7.86). Studies which used 1 and 2 as the cutoff values revealed that mGPS could serve as a prognostic factor for OS. In other pathological types, higher mGPS are also associated with lower OS and CSS. As shown in Table 2, we demonstrated that higher mGPS had a poorer OS (HR=3.54 95%CI, 2.48–5.06) and CSS (HR=5.99 95%CI, 3.94–9.09) in patients with clear cell RCC. While because of the small number of enrolled studies, we only conducted subgroup analyses for CSS based on pathology, stage, and regions. In the present study, we evaluated the association between pretreatment mGPS and prognosis by searching available literature and pooling all outcome data.Ġ: 38 (32.3%) 1: 17 (14.4%) 2: 62 (53.3%)Ġ: 92 (50.8%) 1: 36 (19.9%) 2: 53 (29.3%)Ġ: 267 (75.8%) 1: 38 (10.8%) 2: 47 (13.3%)Ġ: 80 (62.0%) 1: 27 (20.9%) 2: 22 (17.1%)ĭue to obvious heterogeneity among studies, we accomplished subgroup analyses for OS stratified by pathological type, the cutoff value of mGPS, stage, and regions. Therefore, it is necessary to evaluate the prognostic value of mGPS for patients with RCC by conducting a systematic review and meta-analysis. 13, 16 – 18 However, the prognostic value of mGPS for RCC remains unclear, and the findings of different studies are inconsistent. 12 – 15 Modifying GPS as modified Glasgow prognostic score (mGPS), giving a score of 1 only for an elevated CRP, has been considered as a prognostic factor for several cancers such as non-small cell lung cancer, esophageal cancer, hepatocellular carcinoma, as well as RCC. This score has been shown to have prognosis value for various tumors including gastric cancer, non-small cell lung cancer, esophageal cancer, as well as RCC. 10, 11 Glasgow prognostic score (GPS), a combination of CRP and albumin levels, reflects systemic inflammation and nutritional status. 8, 9 Reportedly, an increasing number demonstrated that inflammation biomarkers, such as C-reactive protein (CRP), the neutrophil-to-lymphocyte ratio (NLR), and the platelet-to-lymphocyte ratio (PLR) could predict prognosis of RCC. 6, 7 Currently, more evidence suggested that systemic inflammation is associated with disease development and progression. 5 TNM stage and Fuhrman nuclear grade are widely served as prognostic factors, but these factors have limited accuracy. Stratifications of patients based on the risk of recurrence are important to aid decision-making, to identify further follow-up and to judge whether patients should be enrolled in adjuvant clinical trials. 3 Treatments for metastatic RCC also have developed rapidly, including cytoreductive nephrectomy, immunotherapy, or target therapy, but the clinical outcome is not encouraging. 2 Although the development of treatment for localized RCC, such as radical nephrectomy or partial nephrectomy, approximately 20–40% of patients will have local or distal recurrence. Approximately 67% of newly diagnosed patients are localized disease, 16% of patients present regional or distant metastases. 1 The occurrence of RCC has been increasing over the past three decades. Renal cell carcinoma (RCC) accounts for 2–3% of all cancers, with an estimated 403,262 new cases in the world in 2018. ![]() |
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